Literature summary for 3.4.24.86 extracted from

Wang, X.; Feuerstein, G.Z.; Xu, L.; Wang, H.; Schumacher, W.A.; Ogletree, M.L.; Taub, R.; Duan, J.J.; Decicco, C.P.; Liu, R.
Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats (2004), Mol. Pharmacol., 65, 890-896.

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Application

Application	Comment	Organism
medicine	inhibition of TACE might be a potential therapeutic strategy for neuroprotection after focal ischemic stroke	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
DPH-067517	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
ADAM17	-	Rattus norvegicus
TACE	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000028	-	DPH-067517	-	Rattus norvegicus

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Release 2023.1 (January 2023)