Literature summary for 3.4.24.86 extracted from

Kurz, M.; Pischel, H.; Hartung, H.; Kieseier, B.C.
Tumor necrosis factor-alpha-converting enzyme is expressed in the inflamed peripheral nervous system (2005), J. Peripher. Nerv. Syst., 10, 311-318.

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Application

Application	Comment	Organism
medicine	ADAM-17 is a putative target for treatment of neuroinflammatory diseases	Homo sapiens
medicine	ADAM-17 is a putative target for treatment of neuroinflammatory diseases	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	female, Lewis	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
nerve	sural nerve biopsies from Guillain-Barre syndrome patients. ADAM-17-expressing T cells can be localized primarily within the epi- and perineurium, whereas in control sections from patients with non-inflammatory neuropathies, no axpression can be depected. The enzyme may contribute to the pathogenesis of inflammatory demyelination of the peripheral nervous system	Homo sapiens	-
T-cell	primary cellular source of ADAM-17 in inflamed peripheral nervous system (experimental autoimmune neuritis). Not all T lymphocytes within the inflamed peripheral nervous system express ADAM-17. No ADAM-17 expressing cells are found in nerves from control animals	Rattus norvegicus	-

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Release 2023.1 (January 2023)