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Literature summary for 3.4.24.86 extracted from

  • Lomniczi, A.; Cornea, A.; Costa, M.E.; Ojeda, S.R.
    Hypothalamic tumor necrosis factor-alpha converting enzyme mediates excitatory amino acid-dependent neuron-to-glia signaling in the neuroendocrine brain (2006), J. Neurosci., 26, 51-62.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus TACE-mediated ectodomain shedding of erbB ligands, epitomized by TGFalpha is a key component of the neuron-to-glia signaling mechanism used by excitatory amino acids to facilitate the advent of female puberty ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 immature Sprague Dawley
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Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus within the hypothalamus, TACE is most abundantly expressed in astrocytes of the median eminence, specific changes in TACE activity are required for the normal timimg of puberty. TACE is a component of the neuron-to-glia signaling process used by glutamatergic neurons to control female sexual development Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information TACE-mediated ectodomain shedding of erbB ligands, epitomized by TGFalpha is a key component of the neuron-to-glia signaling mechanism used by excitatory amino acids to facilitate the advent of female puberty Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
TACE
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 Rattus norvegicus