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Literature summary for 3.4.24.86 extracted from
- Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: The juxtamembrane stalk determines cleavage efficiency (2004), J. Biol. Chem., 279, 24179-24188.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | TACE may have a role in phorbol myristate acetate-induced shedding of epiregulin | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
recombinant | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | TACE may have a role in phorbol myristate acetate-induced shedding of epiregulin | Homo sapiens | ? | - |
? | |
| pro amphiregulin + H2O | TACE is capable of cleaving both N- and C-terminal sites in the pro-amphiregulin ectodomain | Homo sapiens | ? | - |
? | |
| pro heparin-binding epidermal growth factor + H2O | purified soluble TACE cleaves a single site in the juxtamembrane stalk of pro heparin-binding epidermal growth factor | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TACE | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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