Application | Comment | Organism |
---|---|---|
medicine | blood borne lethal toxin is a novel therapeutic target for combating anthrax | Bacillus anthracis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dependent on | Bacillus anthracis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
91000 | - |
x * 91000, lethal factor, SDS-PAGE | Bacillus anthracis |
710000 | - |
x * 710000, lethal toxin, SDS-PAGE | Bacillus anthracis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
mitogen-activated protein kinase kinase + H2O | Bacillus anthracis | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Superose 6 gel filtration | Bacillus anthracis |
Storage Stability | Organism |
---|---|
-20°C, purified lethal toxin, at least 3 months, no loss of activity | Bacillus anthracis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
mitogen-activated protein kinase kinase + H2O | - |
Bacillus anthracis | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 710000, lethal toxin, SDS-PAGE | Bacillus anthracis |
? | x * 91000, lethal factor, SDS-PAGE | Bacillus anthracis |
Synonyms | Comment | Organism |
---|---|---|
lethal factor | - |
Bacillus anthracis |
lethal toxin | - |
Bacillus anthracis |
General Information | Comment | Organism |
---|---|---|
physiological function | the Lethal Toxin is formed when up to three molecules of lethal factor bind a 63 kDA protective antigen heptamer. Anthrax lethal toxin is a major virulence factor of Bacillus anthracis. Fully assembled lethal toxin binds an anthrax toxin receptor with almost 100fold higher affinity than the protective antigen alone | Bacillus anthracis |