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Literature summary for 3.4.24.81 extracted from
- ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A (2014), J. Biol. Chem., 289, 13308-13322.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | O35598 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| meprin A + H2O | - |
Mus musculus | ? | during ischemia-reperfusion-induced acute kidney injury, meprin A is shed from proximal tubule membranes. ADAM10 inhibition is sufficient to block shedding, small interfering RNA to ADAM10 inhibits shedding | ? |  |
| meprin beta + H2O | - |
Mus musculus | ? | during ischemia-reperfusion-induced acute kidney injury, meprin beta is shed from proximal tubule membranes. ADAM10 inhibition is sufficient to block shedding, small interfering RNA to ADAM10 inhibits shedding | ? | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ADAM10 is the major ADAM metalloproteinase responsible for the constitutive and stimulated shedding of meprin beta and meprin A | Mus musculus |
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Release 2023.1 (January 2023)
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