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Literature summary for 3.4.24.81 extracted from

  • Pabois, A.; Devalliere, J.; Quillard, T.; Coulon, F.; Gerard, N.; Laboisse, C.; Toquet, C.; Charreau, B.
    The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells (2014), Biochem. Pharmacol., 91, 510-521.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens O14672
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Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell ADAM10 specifically localizes in the CD31+ endothelial cells in normal human cardiac tissues and in cultured primary arterial endothelial cells Homo sapiens
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JURKAT cell
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Homo sapiens
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General Information

General Information Comment Organism
physiological function endopeptidase ADAM10 selectively regulates Notch receptors and ligands in en dothelial cells and promotes Dll4 expression. ADAM10 mediates a canonical Notch dependent release of interleukin IL-6, dependent of gamma-secretase activity. The production of IL-6 through ADAM10/Notch signaling in endothelial cells requires the involvement of the phosphoinositol 3-kinase pathway Homo sapiens