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Literature summary for 3.4.24.81 extracted from
- Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10) (2010), J. Biol. Chem., 285, 22919-22926.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| MEF cell | - |
Mus musculus | - |
| neuron | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nectin 1 + H2O | ADAM10 is the major secretase responsible for nectin-1 ectodomain cleavage in neurons and the brain | Mus musculus | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| a disintegrin and metalloprotease 10 | - |
Mus musculus |
| ADAM10 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | ADAM10 as a major alpha-secretase in the ectodomain shedding of nectin-1 | Mus musculus |
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Release 2023.1 (January 2023)
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