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Literature summary for 3.4.24.81 extracted from

  • Jacobsen, K.T.; Adlerz, L.; Multhaup, G.; Iverfeldt, K.
    Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases (2010), J. Biol. Chem., 285, 10223-10231.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
GI254023X
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-amyloid precursor protein + H2O Homo sapiens
-
sAPP-alpha fragment of beta-amyloid precursor protein + C-terminal fragment of beta-amyloid precursor protein
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein + H2O
-
Homo sapiens sAPP-alpha fragment of beta-amyloid precursor protein + C-terminal fragment of beta-amyloid precursor protein
-
?

Synonyms

Synonyms Comment Organism
ADAM10 alpha-secretase Homo sapiens

General Information

General Information Comment Organism
physiological function ADAM10 activity is required for insulin-like growth factor-1-induced secretion of soluble amyloid-beta precurso protein Homo sapiens