Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
salivary gland | human salivary gland cells are used | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ADAM10 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | to determine the involvement of ADAM10 and ADAM17 in G protein coupled receptor P2Y2 nucleotide receptor-mediated EGFR activation, human salivary gland cells are transfected with small interfering RNA targeting either ADAM10 or ADAM17 mRNA. Transfection of human salivary gland cells with ADAM10 or ADAM17 siRNA partially suppress EGFR and ERK1/2 phosphorylation induced by UTP, whereas co-transfection with both ADAM10 and ADAM17 siRNA almost completely preventd UTP-induced EGFR and ERK1/2 phosphorylation | Homo sapiens |
physiological function | ADAM10 and ADAM17 are activated by G protein-coupled receptor P2Y2 | Homo sapiens |