Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O35598 | - |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | ADAM10 is involved in the proteolytic processing and shedding of proteins such as the amyloid precursor protein, cadherins, and the Notch receptors, thereby initiating the regulated intramembrane proteolysis of these proteins. ADAM10 performs a dual role in cells, as a metalloprotease when it is membrane-bound, and as a potential signaling protein once cleaved by ADAM9/15 and the alpha-secretase | Mus musculus |