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Literature summary for 3.4.24.81 extracted from

  • Tousseyn, T.; Thathiah, A.; Jorissen, E.; Raemaekers, T.; Konietzko, U.; Reiss, K.; Maes, E.; Snellinx, A.; Serneels, L.; Nyabi, O.; Annaert, W.; Saftig, P.; Hartmann, D.; De Strooper, B.
    ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase (2009), J. Biol. Chem., 284, 11738-11747.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus O35598
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General Information

General Information Comment Organism
physiological function ADAM10 is involved in the proteolytic processing and shedding of proteins such as the amyloid precursor protein, cadherins, and the Notch receptors, thereby initiating the regulated intramembrane proteolysis of these proteins. ADAM10 performs a dual role in cells, as a metalloprotease when it is membrane-bound, and as a potential signaling protein once cleaved by ADAM9/15 and the alpha-secretase Mus musculus