Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
FcalphaR + H2O | Homo sapiens | FcaR (CD89) is the Fc receptor for immunoglobulin A. ADAM10 and ADAM17 are involved in the shedding of FcalphaR | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
FcalphaR + H2O | FcaR (CD89) is the Fc receptor for immunoglobulin A. ADAM10 and ADAM17 are involved in the shedding of FcalphaR | Homo sapiens | ? | - |
? | |
FcalphaR + H2O | FcaR (CD89) is the Fc receptor for immunoglobulin A | Homo sapiens | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of both endogenous ADAM10 and endogenous ADAM17 inhibits FcalphaR shedding, demonstrating that ADAM10 and ADAM17 are involved in the shedding of FcalphaR | Homo sapiens |