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Literature summary for 3.4.24.81 extracted from

  • Arduise, C.; Abache, T.; Li, L.; Billard, M.; Chabanon, A.; Ludwig, A.; Mauduit, P.; Boucheix, C.; Rubinstein, E.; Le Naour, F.
    Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor (2008), J. Immunol., 181, 7002-7013.
    View publication on PubMed
Search for more literature for 3.4.24.81

Activating Compound

Activating Compound Comment Organism Structure
tetraspanin several anti-tetraspanin mAbs (CD9, CD81, CD82) increase epidermal growth factor and/or TNF-alpha secretion through a mechanism dependent on ADAM10. The effect of anti-tetraspanin mAb on TNF-alpha release is rapid, not relayed by intercellular signaling, and depends on an intact MEK/Erk1/2 pathway. It is also associated with a concentration of ADAM10 in tetraspanin-containing patches. A large fraction of ADAM10 associates with several tetraspanins Homo sapiens

Application

Application Comment Organism
molecular biology tetraspanins regulate the activity of ADAM10 toward several substrates. It is illustrated how membrane compartmentalization by tetraspanins can control the function of cell surface proteins such as ectoproteases Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GI254023X
-
 Homo sapiens
GW280264X
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEL cell
-
 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-
RAJI cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
epidermal growth factor + H2O
-
 Homo sapiens ?
-
 ?
TNF-alpha + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAM10
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens