Activating Compound | Comment | Organism | Structure |
---|---|---|---|
staurosporine | ADAM10-mediated proteolysis of VE-cadherin is induced | Homo sapiens |
Application | Comment | Organism |
---|---|---|
molecular biology | ADAM10 is regulator of vascular permeability and possesses a function VE-cadherin-dependent endothelial cell functions and leukocyte transendothelial migration | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in HUVEC and COS-7 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | increased ADAM10 expression is functionally associated with an increase in endothelial permeability. ADAM10 activity also contributes to the thrombin-induced decrease of endothelial cell-cell adhesion | Homo sapiens |
additional information | knockdown of ADAM10 in HUVECs as well as in T cells by small interfering RNA impairs T-cell transmigration | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | ADAM10-mediated proteolysis of VE-cadherin is induced by Ca2+ influx | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
VE-cadherin + H2O | VE-cadherin is specifically cleaved by the disintegrin and metalloprotease ADAM10 in its ectodomain, releasing a soluble fragment and generating a carboxyl-terminal membrane-bound stub, which is a substrate for a subsequent gamma-secretase cleavage | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAM10 | - |
Homo sapiens |