Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3)Star cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
C173S | mutation does not impair the inhibitory potency of the ADAM10 prodomain against ADAM10 | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADAM10 prodomain Pro-A10 WT 23-213 (C-terminal His tag) | 48 nM, specific inhibitor | Mus musculus | |
ADAM10 prodomain Pro-A10 WT 23-213 (N-terminal His tag) | 75 nM, specific inhibitor | Mus musculus | |
ADAM10 prodomain ProA10 C173S 23-213 (C-terminal His tag) | 36 nM, specific inhibitor | Mus musculus | |
ADAM8 prodomain Pro-A8 | 25% inhibition at 0.003 mM | Mus musculus | |
GI254023X | specific inhibitor | Mus musculus | |
TACE prodomain Pro-A17 | 11% inhibition at 0.0035 mM | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni2+-NTA column chromatography and Superdex-75 gel filtration | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-amyloid precursor protein + H2O | - |
Mus musculus | sAPP-alpha fragment + C-terminal fragment | - |
? | |
betacellulin + H2O | - |
Mus musculus | ? | - |
? | |
dabcyl-LAQA(homoPhe)RSC(fluorescein)-NH2 + H2O | - |
Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
a disintegrin and metalloproteinase 10 | - |
Mus musculus |
ADAM10 | - |
Mus musculus |