Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.81 extracted from

  • Moss, M.L.; Bomar, M.; Liu, Q.; Sage, H.; Dempsey, P.; Lenhart, P.M.; Gillispie, P.A.; Stoeck, A.; Wildeboer, D.; Bartsch, J.W.; Palmisano, R.; Zhou, P.
    The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events (2007), J. Biol. Chem., 282, 35712-35721.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3)Star cells Mus musculus

Protein Variants

Protein Variants Comment Organism
C173S mutation does not impair the inhibitory potency of the ADAM10 prodomain against ADAM10 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
ADAM10 prodomain Pro-A10 WT 23-213 (C-terminal His tag) 48 nM, specific inhibitor Mus musculus
ADAM10 prodomain Pro-A10 WT 23-213 (N-terminal His tag) 75 nM, specific inhibitor Mus musculus
ADAM10 prodomain ProA10 C173S 23-213 (C-terminal His tag) 36 nM, specific inhibitor Mus musculus
ADAM8 prodomain Pro-A8 25% inhibition at 0.003 mM Mus musculus
GI254023X specific inhibitor Mus musculus
TACE prodomain Pro-A17 11% inhibition at 0.0035 mM Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni2+-NTA column chromatography and Superdex-75 gel filtration Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein + H2O
-
Mus musculus sAPP-alpha fragment + C-terminal fragment
-
?
betacellulin + H2O
-
Mus musculus ?
-
?
dabcyl-LAQA(homoPhe)RSC(fluorescein)-NH2 + H2O
-
Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloproteinase 10
-
Mus musculus
ADAM10
-
Mus musculus