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Literature summary for 3.4.24.81 extracted from

  • Lemieux, G.A.; Blumenkron, F.; Yeung, N.; Zhou, P.; Williams, J.; Grammer, A.C.; Petrovich, R.; Lipsky, P.E.; Moss, M.L.; Werb, Z.
    The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10 (2007), J. Biol. Chem., 282, 14836-14844.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information not stimulated by sphingosine 1-phosphate Homo sapiens

Application

Application Comment Organism
medicine potential therapeutic target for the treatment of allergic diseases Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
E385A inactive Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GM6001 inhibits 50-60% of CD23 shedding Homo sapiens
TAPI-2 inhibits 70% of CD23 shedding Homo sapiens
TIMP-1 modest inhibitory activity toward CD23 shedding Homo sapiens
TIMP-2 modest inhibitory activity toward CD23 shedding Homo sapiens
TIMP-3 modest inhibitory activity toward CD23 shedding Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4-dinitrophenyl-EVHHQKLVFFAE + H2O
-
Homo sapiens ?
-
?
2,4-dinitrophenyl-HGDQMAQKSQST + H2O
-
Homo sapiens ?
-
?
2,4-dinitrophenyl-LPQLENVKGTED + H2O
-
Homo sapiens ?
-
?
2,4-dinitrophenyl-RAEQQRLKSQDL + H2O
-
Homo sapiens ?
-
?
2,4-dinitrophenyl-SPLAQAVRSSSR + H2O
-
Homo sapiens ?
-
?
CD23 + H2O
-
Homo sapiens ?
-
?
dabcyl-LAQA(homoPhe)RSC(fluorescein)-NH2 + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloproteinase 10
-
Homo sapiens
ADAM10
-
Homo sapiens