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Literature summary for 3.4.24.81 extracted from

  • Ludwig, A.; Hundhausen, C.; Lambert, M.H.; Broadway, N.; Andrews, R.C.; Bickett, D.M.; Leesnitzer, M.A.; Becherer, J.D.
    Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules (2005), Comb. Chem. High Throughput Screen., 8, 161-171.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
((2R,3S)-3-(formyl-hydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid)[(1S)-2,2-dimethyl-1-methylcarbamoyl-1-propyl]amide compound GI254023X, IC50: 5.3 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein + H2O
-
Homo sapiens sAPP-alpha fragment of beta-amyloid precursor protein + C-terminal fragment of beta-amyloid precursor protein
-
?
biotin-SPLAQAVRSSSRTPS-NH2 + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ADAM10
-
Homo sapiens
transmembrane metzinkin-protease of the a disintegrin and metalloproteinase family-10
-
Homo sapiens