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Literature summary for 3.4.24.81 extracted from

  • Lopez-Perez, E.; Zhang, Y.; Frank, S.J.; Creemers, J.; Seidah, N.; Checler, F.
    Constitutive a-secretase cleavage of the b-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10 (2001), J. Neurochem., 76, 1532-1539.
    View publication on PubMed

Application

Application Comment Organism
medicine cleavage by ADAM10 of beta-amyloid precursor protein could abolish production of longer peptides and slow down or arrest Alzheimer disease Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell associated
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-amyloid precursor protein Homo sapiens LoVo cell line overexpressing ADAM10 secreted a 185% of sAPP-alpha over control values sAPP-alpha fragment + C-terminal fragment
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
cell line
-

Purification (Commentary)

Purification (Comment) Organism
SDS-PAGE Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney cell line wild type cell line Homo sapiens
-
LoVo cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein LoVo cell line overexpressing ADAM10 secreted a 185% of sAPP-alpha over control values Homo sapiens sAPP-alpha fragment + C-terminal fragment
-
?