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Literature summary for 3.4.24.81 extracted from

  • Vincent, B.; Paitel, E.; Saftig, P.; Frobert, Y.; Hartmann, D.; De Strooper, B.; Grassi, J.; Lopez-Perez, E.; Checler, F.
    The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein (2001), J. Biol. Chem., 276, 37743-37746.
    View publication on PubMed
Search for more literature for 3.4.24.81

Activating Compound

Activating Compound Comment Organism Structure
additional information
-
 Mus musculus
additional information cells overexpressing ADAM10 are not responsive to phorbol ester-induced cleavage, indicating constitutive activity and not Protein kinase C induced activity Homo sapiens

Application

Application Comment Organism
medicine cleavage by metalloproteinase ADAM10 of PrP cellular protein is constitutive and could inhibit the maintenance of the toxic core of the protein PrP scrapie in spongiform encephalopathies Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
BB3103 0.01 mM inhibitory but not completely Homo sapiens
BB3103 0.01 mM inhibitory but not completely Mus musculus
additional information serine, thiol and acidic protease inhibitors are not inhibitory Homo sapiens
additional information serine, thiol and acidic protease inhibitors are not inhibitory Mus musculus
o-phenanthroline inhibit activity 0.1 mM Homo sapiens
o-phenanthroline inhibit activity 0.1 mM Mus musculus
TAPI 0.01 mM inhibitory but not completely Homo sapiens
TAPI 0.01 mM inhibitory but not completely Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell associated
-
 Mus musculus
-
-
cell associated
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cellular prion protein Mus musculus constitutive protein cleavage N1 fragment + C-terminal fragment
-
 ?
cellular prion protein Homo sapiens constitutive protein cleavage N1 fragment + C-terminal fragment
-
 ?
cellular prion protein Mus musculus knock out line has 51% of reduction in N1 formation N1 fragment + C-terminal fragment
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 cell line
-
Mus musculus
-
 mouse cell line
-

Purification (Commentary)

Purification (Comment) Organism
SDS-PAGE Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast cell line embryonic knock out fibroblast for ADAM10 Mus musculus
-
HEK-293 cell embryonic wild type cell line and overexpressing ADAM10 Homo sapiens
-
neuronal cell line TSM1 cell line Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cellular prion protein constitutive protein cleavage Mus musculus N1 fragment + C-terminal fragment
-
 ?
cellular prion protein constitutive protein cleavage Homo sapiens N1 fragment + C-terminal fragment
-
 ?
cellular prion protein knock out line has 51% of reduction in N1 formation Mus musculus N1 fragment + C-terminal fragment
-
 ?