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Literature summary for 3.4.24.7 extracted from

  • Zeldich, E.; Koren, R.; Dard, M.; Weinberg, E.; Weinreb, M.; Nemcovsky, C.E.
    Enamel matrix derivative induces the expression of tissue inhibitor of matrix metalloproteinase-3 in human gingival fibroblasts via extracellular signal-regulated kinase (2010), J. Periodontal Res., 45, 200-206.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
TIMP-1 no apparent regulation of the expression of TIMP-1 by either tumor necrosis factor or enamel matrix derivative Homo sapiens
TIMP-3 is induced by enamel matrix derivative Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens matrix metalloproteinases are endopeptidases capable of cleaving various components of extracellular matrix ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast gingival, gingival fibroblasts produce MMP-1 in response to inflammatory cytokines, such as TNF and interleukin-1 Homo sapiens
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gingiva connective tissue Homo sapiens
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additional information MMP-1 expression analysis in gingival tissue, overview Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information matrix metalloproteinases are endopeptidases capable of cleaving various components of extracellular matrix Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-1
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 Homo sapiens
MMP-1
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens MMP-1 is induced in gingival fibroblasts in response to inflammatory cytokines, such as TNF and interleukin-1. TNF treatment of human gingival fibroblasts significantly induces the expression of MMP-1 severalfold, while enamel matrix derivative alone has no effect up

General Information

General Information Comment Organism
malfunction periodontal disease is characterized by increased expression and activity of matrix metalloproteinases and insufficient expression/activity of their inhibitors, tissue inhibitors of matrix metalloproteinases, TIMPs. This altered MMP-TIMP balance results in progressive destruction of gingival and periodontal extracellular matrix Homo sapiens