Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.7 extracted from

  • Poulalhon, N.; Farge, D.; Roos, N.; Tacheau, C.; Neuzillet, C.; Michel, L.; Mauviel, A.; Verrecchia, F.
    Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug rapamycin. A direct role as an antifibrotic agent? (2006), J. Biol. Chem., 281, 33045-33052.
    View publication on PubMed
Search for more literature for 3.4.24.7

Activating Compound

Activating Compound Comment Organism Structure
additional information rapamycin-induced MMP-1 gene transactivation and AP-1/DNA interactions, rapamycin significantly enhances the expression of interstitial collagenase at the protein and mRNA levels and transcriptionally, rapamycin efficiently activates activator protein-1, AP-1-driven transcription by rapidly inducing c-jun/AP-1 phosphorylation with activation of the c-Jun N-terminal kinase cascade, resulting in enhanced binding of AP-1-DNA complex formation and AP-1-dependent gene transactivation, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
integrity of MMP-1 promoter AP-1 binding site is necessary for transactivation by rapamycin, regulation, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the JNK inhibitor SP600125 inhibits rapamycin-induced MMP-1 gene transactivation and AP-1/DNA interactions, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen I + H2O Homo sapiens degradation ?
-
 ?
additional information Homo sapiens enzyme regulation on expression and protein levels, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast from lung Homo sapiens
-
WI-26 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen I + H2O degradation Homo sapiens ?
-
 ?
additional information enzyme regulation on expression and protein levels, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP-1
-
 Homo sapiens