Literature summary for 3.4.24.46 extracted from

Trochon-Joseph, V.; Martel-Renoir, D.; Mir, L.M.; Thomaidis, A.; Opolon, P.; Connault, E.; Li, H.; Grenet, C.; Fauvel-Lafeve, F.; Soria, J.; Legrand, C.; Soria, C.; Perricaudet, M.; Lu, H.
Evidence of antiangiogenic and antimetastatic activities of the recombinant disintegrin domain of metargidin (2004), Cancer Res., 64, 2062-2069.

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Application

Application	Comment	Organism
medicine	recombinant disintegrin domain of enzyme, shows inhibitory activities on endothelial cell proliferation and adhesion on the integrin substrates fibronectin, vitronectin, and fibrinogen.The domain totally abrogates endothelial cell migration and blocks most capillary formation in a three-dimensional fibrin gel. Athymic mice bearing electrotransferred domain exhibit strong inhibition of tumor angiogenesis	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	recombinant disintegrin domain of enzyme, shows inhibitory activities on endothelial cell proliferation and adhesion on the integrin substrates fibronectin, vitronectin, and fibrinogen.The domain totally abrogates endothelial cell migration and blocks most capillary formation in a three-dimensional fibrin gel. Athymic mice bearing electrotransferred domain exhibit strong inhibition of tumor angiogenesis	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	disintegrin domain of enzyme acts as inhibitor of angiogenesis, tumor growth, and metastasis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant disintegrin domain of enzyme	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	disintegrin domain of enzyme acts as inhibitor of angiogenesis, tumor growth, and metastasis	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
metargidin	-	Homo sapiens

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Release 2023.1 (January 2023)