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Literature summary for 3.4.24.35 extracted from

  • Monsonego-Ornan, E.; Kosonovsky, J.; Bar, A.; Roth, L.; Fraggi-Rankis, V.; Simsa, S.; Kohl, A.; Sela-Donenfeld, D.
    Matrix metalloproteinase 9/gelatinase B is required for neural crest cell migration (2012), Dev. Biol., 364, 162-177.
    View publication on PubMed
Search for more literature for 3.4.24.35

Cloned(Commentary)

Cloned (Comment) Organism
gene MMP9, cloning of an enzyme fragment, containing an ATG start codon, signal peptide, prodomain sequence, active site, fibronectin II repeat domain and zinc binding sequence,from chondrocyte cDNA, stable recombinant expression in a rat chondrosarcoma cell line Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
MMP9 inhibitor I
-
 Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metalloprotease Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Gallus gallus
-
 ?
-
 ?
Gelatin + H2O Gallus gallus Lohman
-
 ?
-
 ?
Laminin + H2O Gallus gallus degradation ?
-
 ?
Laminin + H2O Gallus gallus Lohman degradation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Gallus gallus Lohman
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte
-
 Gallus gallus
-
embryo in the lumen of the cranial and cervical neural tubes Gallus gallus
-
neural crest cell distribution of MMP9 in both emigrating and migrating neural crest cells, overview Gallus gallus
-
neural tube
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
 Gallus gallus ?
-
 ?
Gelatin + H2O
-
 Gallus gallus Lohman ?
-
 ?
Laminin + H2O degradation Gallus gallus ?
-
 ?
Laminin + H2O degradation Gallus gallus Lohman ?
-
 ?

Synonyms

Synonyms Comment Organism
gelatinase B
-
 Gallus gallus
Matrix metalloproteinase 9
-
 Gallus gallus
MMP9
-
 Gallus gallus

General Information

General Information Comment Organism
malfunction enzyme inhibition prevents neural crest cells delamination and migration Gallus gallus
additional information enzyme MMP9 promotes neural crest cell emigration from the neural tube by enhancing breakage of laminin at the basement-membrane, mechanism of activity, overview Gallus gallus
physiological function enzyme matrix metalloproteinase 9/gelatinase B is required for neural crest cell migration, which are neuroepithelial progenitors that convert into mesenchyme and migrate along defined paths throughout the embryo. The enzyme plays a role during neural crest cell detachment from the neural tube, overview Gallus gallus