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Literature summary for 3.4.24.35 extracted from

  • Perng, D.W.; Chang, K.T.; Su, K.C.; Wu, Y.C.; Chen, C.S.; Hsu, W.H.; Tsai, C.M.; Lee, Y.C.
    Matrix metalloprotease-9 induces transforming growth factor-beta1 production in airway epithelium via activation of epidermal growth factor receptors (2011), Life Sci., 89, 204-212.
    View publication on PubMed

Application

Application Comment Organism
medicine MMP-9 induces TGF-beta1 production in the airway epithelium through the cleavage of EGF and EGF-like ligands and activating EGFR, suggesting potential targets of therapeutic intervention in airway fibrotic disorders Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
epidermal growth factor + H2O Homo sapiens MMP-9 induces TGF-beta1 production in the airway epithelium through the cleavage of epidermal growth factor, EGF, and membrane-bound EGF-like ligands and activating epidermal growth factor receptor ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium airway Homo sapiens
-
lung parenchyma from surgical lobectomy for lung cancer Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
epidermal growth factor + H2O
-
Homo sapiens ?
-
?
epidermal growth factor + H2O MMP-9 induces TGF-beta1 production in the airway epithelium through the cleavage of epidermal growth factor, EGF, and membrane-bound EGF-like ligands and activating epidermal growth factor receptor Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
matrix metalloprotease-9
-
Homo sapiens
MMP-9
-
Homo sapiens

General Information

General Information Comment Organism
physiological function MMP-9 significantly induced Smad3 phosphorylation and subsequent fibroblast proliferation. MMP cleaves membrane-bound precursor proteins and releases epidermal growth factor-like ligands that subsequently bind to epidermal growth factor receptor, and it stimulates the airway epithelium to produce fibrogenic mediators through activation of membrane-bound receptors. MMP-9 is required to cleave membrane-bound growth factors Homo sapiens