Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.35 extracted from

  • Franco, G.C.; Kajiya, M.; Nakanishi, T.; Ohta, K.; Rosalen, P.L.; Groppo, F.C.; Ernst, C.W.; Boyesen, J.L.; Bartlett, J.D.; Stashenko, P.; Taubman, M.A.; Kawai, T.
    Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo (2011), Exp. Cell Res., 317, 1454-1464.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.35

Inhibitors

Inhibitors Comment Organism Structure
doxycycline inhibitory mechanism and effect on osteoclastogenesis signaling induced by RANKL, both in vitro and in vivo, overview. Although Dox inhibits RANKL-induced osteoclastogenesis and down-modulates the mRNA expression of functional osteoclast markers, it neither affects RANKL-induced MAPKs phosphorylation nor NFATc1 gene expression in RAW264.7 monocytic cells Mus musculus
MMP-9 inhibitor I
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Mus musculus
-
 ?
-
 ?
Gelatin + H2O Mus musculus BALB/c
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus BALB/c
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow-derived monocyte-macrophage cell
-
 Mus musculus
-
commercial preparation
-
 Mus musculus
-
monocyte
-
 Mus musculus
-
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
 Mus musculus ?
-
 ?
Gelatin + H2O
-
 Mus musculus BALB/c ?
-
 ?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-9
-
 Mus musculus
MMP9
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus auto-amplified NFATc1 plays a key role in upregulating MMP-9 up

General Information

General Information Comment Organism
malfunction inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo, overview. Doxycycline treatment abrogates RANKL-induced osteoclastogenesis and TRAP activity in mouse calvaria along with the suppression of MMP9 enzyme activity, again without affecting the expression of MMP9 protein Mus musculus
metabolism auto-amplified NFATc1 plays a key role in upregulating expressions of genes required for osteoclastmaturation, such as TRAP, cathepsin K, or MMP-9,which are requisite for the bone resorption processes mediated by mature osteoclasts Mus musculus