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Literature summary for 3.4.24.35 extracted from
- Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells (2010), Biomed. Pharmacother., 64, 118-123.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| macrophage | macrophages derived from THP-1 cells | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gelatin + H2O | - |
Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| matrix metalloproteinase-9 | - |
Homo sapiens |
| MMP-9 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | after 24 h incubation, 0.05 mg/ml aspirin inhibits MMP-9 mRNA expression by 50%. MMP-9 mRNA expression and release are inhibited by fenofibrate (0.1 mM) and 15d-prostaglandin J2 (0.005 mM) | down |
| Homo sapiens | MMP-9 mRNA expression and release are induced by 0.002 mM prostaglandin E2 | up |
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