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Literature summary for 3.4.24.35 extracted from
- Matrix metalloproteinase-9 activity and expression is reduced by melatonin during prevention of ethanol-induced gastric ulcer in mice (2007), J. Pineal Res., 43, 56-64.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Melatonin | i.e. N-acetyl-5-methoxytryptamine, used in protection during gastric ulcer, arresting cell injury, protein carbonyl formation, and lipid peroxidation in mice during gastroprotection, inhibits MMP-9 expression and activity | Mus musculus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | MMP-9 is secreted | Mus musculus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Mus musculus | |
| Zn2+ | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gelatin + H2O | Mus musculus | - |
? | - |
? | |
| Gelatin + H2O | Mus musculus BALB/c | - |
? | - |
? | |
| additional information | Mus musculus | MMP-9 plays an important role in degradation of gastric extracellular matrix proteins, MMP-9 is reduced by melatonin produced during gastric ulcer development, overview | ? | - |
? | |
| additional information | Mus musculus BALB/c | MMP-9 plays an important role in degradation of gastric extracellular matrix proteins, MMP-9 is reduced by melatonin produced during gastric ulcer development, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
Balb/c mice | - |
| Mus musculus BALB/c | - |
Balb/c mice | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native MMP-9 from gastric mucosa | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gastric ulcer | induced by ethanol | Mus musculus | - |
| stomach | gastric mucosa | Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gelatin + H2O | - |
Mus musculus | ? | - |
? | |
| Gelatin + H2O | gelatin zymography, gelatin from porcine skin | Mus musculus | ? | - |
? | |
| Gelatin + H2O | - |
Mus musculus BALB/c | ? | - |
? | |
| Gelatin + H2O | gelatin zymography, gelatin from porcine skin | Mus musculus BALB/c | ? | - |
? | |
| additional information | MMP-9 plays an important role in degradation of gastric extracellular matrix proteins, MMP-9 is reduced by melatonin produced during gastric ulcer development, overview | Mus musculus | ? | - |
? | |
| additional information | MMP-9 plays an important role in degradation of gastric extracellular matrix proteins, MMP-9 is reduced by melatonin produced during gastric ulcer development, overview | Mus musculus BALB/c | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| matrix metalloproteinase-9 | - |
Mus musculus |
| MMP-9 | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
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Release 2023.1 (January 2023)
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