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Literature summary for 3.4.24.35 extracted from

  • Ho, T.Y.; Yan, W.; Bagnell, C.A.
    Relaxin-induced matrix metalloproteinase-9 expression is associated with activation of the NF-kappaB pathway in human THP-1 cells (2007), J. Leukoc. Biol., 81, 1303-1310.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information relaxin induces enzyme expression in THP-1 cells, while it reduces expression of NF-kappaB inhibitor protein, IkappaB-alpha, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information pre-exposure to pyrrolidine dithiocarmate suppresses pro-MMP-9 activity and protein levels in relaxin-treated THP-1 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Homo sapiens
-
?
-
?
additional information Homo sapiens MMP-9 is secreted by macrophages at wound sites and is involved in wound repair together with relaxin, molecular mechanism, overview. Transcription factor NF-kappaB is important in MMP gene regulation in macrophage cells, overview, relaxin-induced tissue remodeling through increasing MMP-9 expression is dependent on NF-kappaB activation ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage secretion of MMP-9, transcription factor NF-kappaB is important in MMP gene regulation in macrophage cells Homo sapiens
-
THP-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
Homo sapiens ?
-
?
Gelatin + H2O gelatin zymography Homo sapiens ?
-
?
additional information MMP-9 is secreted by macrophages at wound sites and is involved in wound repair together with relaxin, molecular mechanism, overview. Transcription factor NF-kappaB is important in MMP gene regulation in macrophage cells, overview, relaxin-induced tissue remodeling through increasing MMP-9 expression is dependent on NF-kappaB activation Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-9
-
Homo sapiens
MMP-9
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens