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Literature summary for 3.4.24.35 extracted from

  • Moroy, G.; Denhez, C.; El Mourabit, H.; Toribio, A.; Dassonville, A.; Decarme, M.; Renault, J.H.; Mirand, C.; Bellon, G.; Sapi, J.; Alix, A.J.; Hornebeck, W.; Bourguet, E.
    Simultaneous presence of unsaturation and long alkyl chain at P1 of Ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9) inhibition as shown by molecular modelling studies (2007), Bioorg. Med. Chem., 15, 4753-4766.
    View publication on PubMed
Search for more literature for 3.4.24.35

Activating Compound

Activating Compound Comment Organism Structure
additional information activation of pro-MMP-9 by 4-aminophenylmercuric acetate Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2E)-3-(N-hydroxycarbamoyl)-2-(3-phenylpropylidene)propionyl-L-tryptophan-N-methylamide
-
 Homo sapiens
(2E)-3-(N-hydroxycarbamoyl)-2-heptylidenepropionyl-L-tryptophan-N-methylamide
-
 Homo sapiens
(2E)-3-(N-hydroxycarbamoyl)-2-isopropionyl-L-tryptophan-N-methylamide
-
 Homo sapiens
(2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-3-phenylprop-2-en-1-ylidene]propionyl-L-tryptophan-N-methylamide
-
 Homo sapiens
(2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-but-2-en-1-ylidene]propionyl-L-tryptophan-N-methylamide
-
 Homo sapiens
ilomastat
-
 Homo sapiens
additional information inhibitor synthesis and molecular docking, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information activation of pro-MMP-2 by 4-aminophenylmercuric acetate Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant pro-MMP-9 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4-dinitrophenyl-Pro-beta-cyclohexylalanyl-Gly-Cys(Me)-His-Ala-Lys(N-Me-2-aminobenzoyl)-NH2 + H2O a quenched fluorogenic substrate Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
gelatinase B
-
 Homo sapiens
MMP-9
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000005
-
-
 Homo sapiens ilomastat
0.000017
-
-
 Homo sapiens (2E)-3-(N-hydroxycarbamoyl)-2-isopropionyl-L-tryptophan-N-methylamide
0.000038
-
-
 Homo sapiens (2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-3-phenylprop-2-en-1-ylidene]propionyl-L-tryptophan-N-methylamide
0.000045
-
-
 Homo sapiens (2E)-3-(N-hydroxycarbamoyl)-2-(3-phenylpropylidene)propionyl-L-tryptophan-N-methylamide
0.000974
-
-
 Homo sapiens (2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-but-2-en-1-ylidene]propionyl-L-tryptophan-N-methylamide
0.01
-
 above Homo sapiens (2E)-3-(N-hydroxycarbamoyl)-2-heptylidenepropionyl-L-tryptophan-N-methylamide