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Literature summary for 3.4.24.35 extracted from

  • Kridel, S.J.; Chen, E.; Kotra, L.P.; Howard, E.W.; Mobashery, S.; Smith, J.W.
    Substrate hydrolysis by matrix metalloproteinase-9 (2001), J. Biol. Chem., 276, 20572-20578.
    View publication on PubMed
Search for more literature for 3.4.24.35

Application

Application Comment Organism
medicine MMP-9 is suggested as a regulator of the angiogenic switch in tumor development Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
cDNA encoding the catalytic domain cloned into pCDNA3 and used to transfect HEK 293 cells Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.5
-
 SGPLFYSVTA pH 7.5, 37°C, peptide A10 Mus musculus
0.8
-
 SGFGSRYLTA pH 7.5, 37°C, peptide A19 Mus musculus
1
-
 SGQPHYLTTA pH 7.5, 37°C, peptide B1 Mus musculus
1.3
-
 SGKIPRTLTA pH 7.5, 37°C, peptide A11 Mus musculus
1.4
-
 SGKIPRRLTA pH 7.5, 37°C, peptide A11m1 Mus musculus
2.4
-
 SGLKALMITA pH 7.5, 37°C, peptide A7 Mus musculus
2.9
-
 SGPRAVSTTA pH 7.5, 37°C, peptide A6 Mus musculus
3.7
-
 SGKGPRQITA pH 7.5, 37°C, peptide C15 Mus musculus
4.7
-
 SGKIPRTATA pH 7.5, 37°C, peptide A11m2 Mus musculus
13.5
-
 SGLRPAKSTA pH 7.5, 37°C, peptide A18 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 mouse
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADAM 2 + H2O putative protein substrate with potential cleavage site Mus musculus ?
-
 ?
aggrecan + H2O
-
 Mus musculus ?
-
 ?
alpha 1(I) collagen + H2O
-
 Mus musculus ?
-
 ?
alpha 1(V) collagen + H2O
-
 Mus musculus ?
-
 ?
alpha 1(XI) collagen + H2O
-
 Mus musculus ?
-
 ?
alpha 2(V) collagen + H2O
-
 Mus musculus ?
-
 ?
Cartilage link protein + H2O
-
 Mus musculus ?
-
 ?
CB3 alpha 1(IV) collagen + H2O
-
 Mus musculus ?
-
 ?
desmoglein 3 + H2O putative protein substrate with potential cleavage site Mus musculus ?
-
 ?
endoglin + H2O putative protein substrate with potential cleavage site Mus musculus ?
-
 ?
endothilin receptor + H2O putative protein substrate with potential cleavage site Mus musculus ?
-
 ?
galectin 3 + H2O
-
 Mus musculus ?
-
 ?
integrin beta5 + H2O putative protein substrate with potential cleavage site Mus musculus ?
-
 ?
kallikrein + H2O putative protein substrate with potential cleavage site Mus musculus ?
-
 ?
ladinin 1 + H2O putative protein substrate with potential cleavage site Mus musculus ?
-
 ?
laminin alpha3 chain + H2O putative protein substrate with potential cleavage site Mus musculus ?
-
 ?
additional information peptide A16 SGRR LLSRTA and peptide C11 SGRR LIHHTA are no substrates Mus musculus ?
-
 ?
myelin basic protein + H2O
-
 Mus musculus ?
-
 ?
phosphate regulating neutral endopeptidase + H2O putative protein substrate with potential cleavage site Mus musculus ?
-
 ?
SGFGSRYLTA + H2O
-
 Mus musculus ?
-
 ?
SGKGPRQITA + H2O
-
 Mus musculus ?
-
 ?
SGKIPRRLTA + H2O
-
 Mus musculus ?
-
 ?
SGKIPRTATA + H2O
-
 Mus musculus ?
-
 ?
SGKIPRTLTA + H2O
-
 Mus musculus ?
-
 ?
SGLKALMITA + H2O
-
 Mus musculus ?
-
 ?
SGLKAMITA + H2O
-
 Mus musculus ?
-
 ?
SGLPAKSTA + H2O
-
 Mus musculus ?
-
 ?
SGLRPAKSTA + H2O
-
 Mus musculus ?
-
 ?
SGPLFYSVTA + H2O
-
 Mus musculus ?
-
 ?
SGPRAVSTTA + H2O
-
 Mus musculus ?
-
 ?
SGQPHYLTTA + H2O
-
 Mus musculus ?
-
 ?
tissue factor pathway inhibitor + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-9
-
 Mus musculus
MMP-9
-
 Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
9
-
 SGQPHYLTTA pH 7.5, 37°C, peptide B1 Mus musculus
9.4
-
 SGKIPRTATA pH 7.5, 37°C, peptide A11m2 Mus musculus
11
-
 SGFGSRYLTA pH 7.5, 37°C, peptide A19 Mus musculus
20
-
 SGPLFYSVTA pH 7.5, 37°C, peptide A10 Mus musculus
30
-
 SGLKALMITA pH 7.5, 37°C, peptide A7 Mus musculus
78
-
 SGLRPAKSTA pH 7.5, 37°C, peptide A18 Mus musculus
86.4
-
 SGKIPRTLTA pH 7.5, 37°C, peptide A11 Mus musculus
178
-
 SGPRAVSTTA pH 7.5, 37°C, peptide A6 Mus musculus
224
-
 SGKIPRRLTA pH 7.5, 37°C, peptide A11m1 Mus musculus
703
-
 SGKGPRQITA pH 7.5, 37°C, peptide C15 Mus musculus