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Literature summary for 3.4.24.35 extracted from

  • Pourmotabbed, T.; Aelion, J.A.; Tyrrell, D.; Hasty, K.A.; Bu, C.H.; Mainardi, C.L.
    Role of the conserved histidine and aspartic acid residues in activity and stabilization of human gelatinase B: an example of matrix metalloproteinases (1995), J. Protein Chem., 14, 527-535.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Calcium required Homo sapiens
Zinc required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens plays a role in tumor cell invasion and in destruction of cartilage in arthritis ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Asp432, Asp433, and His400 residues are important for the activity of gelatinase B, His400 may act as a zinc-binding ligand, Asp432 and Asp433 are probably involved in stabilization of the active site of the enzyme Homo sapiens ?
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?
additional information plays a role in tumor cell invasion and in destruction of cartilage in arthritis Homo sapiens ?
-
?