Literature summary for 3.4.24.34 extracted from

Thirkettle, S.; Decock, J.; Arnold, H.; Pennington, C.; Jaworski, D.; Edwards, D.
Matrix metalloproteinase 8 (collagenase 2) induces the expression of interleukins 6 and 8 in breast cancer cells (2013), J. Biol. Chem., 288, 16282-16294.

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Application

Application	Comment	Organism
medicine	breast cancer cell lines MCF-7, SKBR-3, and MDA-MB-231 expressing wild-type MMP-8 reveal elevated levels of interleukins IL-6 and IL-8. This increase is mirrored at the mRNA level and is dependent on MMP-8 catalytic activity. Sustained expression of wild-type MMP-8 by breast cancer cells is non-permissive for long-term growth.In long-term culture of transfected MDA-MB-231 cells, expression of wild-type but not E198A mutant MMP-8 is lost, with IL-6 and IL-8 levels returning to base line	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
E198A	catalytically inactive	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P22894	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-
SK-BR-3 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)