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Literature summary for 3.4.24.34 extracted from

  • Mazzini, F.; Nuti, E.; Petri, A.; Rossello, A.
    Immobilization of matrix metalloproteinase 8 (MMP-8) for online drug screening (2011), J. Chromatogr. B, 879, 756-762.
    View publication on PubMed
Search for more literature for 3.4.24.34

Application

Application Comment Organism
biotechnology human MMP-8 is coupled to epoxy activated silica matrix in an immobilized enzyme reactor which is used for the online screening of known MMP-8 inhibitors in zonal chromatography and inhibition experiments Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-hydroxy-2-(2-[[4-(4-methoxyphenoxy)phenyl]sulfonyl]phenyl)acetamide
-
 Homo sapiens
N-hydroxy-N2-[(4'-methoxybiphenyl-4-yl)sulfonyl]-N2-(propan-2-yloxy)glycinamide
-
 Homo sapiens
N-hydroxy-N2-[(4-phenoxyphenyl)sulfonyl]-N2-(propan-2-yloxy)glycinamide
-
 Homo sapiens
N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)glycinamide
-
 Homo sapiens
N2-(biphenyl-4-ylsulfonyl)-N-hydroxyglycinamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Mca-Lys-Pro-Leu-Gly + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP-8
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000005
-
 pH 7.5, 37°, free MMP-8 FLU plates read Homo sapiens N-hydroxy-2-(2-[[4-(4-methoxyphenoxy)phenyl]sulfonyl]phenyl)acetamide
0.000007
-
 pH 7.5, 37°, free MMP-8 FLU plates read Homo sapiens N2-(biphenyl-4-ylsulfonyl)-N-hydroxyglycinamide
0.00001
-
 pH 7.5, 37°, free MMP-8 HPLC-FLU Homo sapiens N-hydroxy-2-(2-[[4-(4-methoxyphenoxy)phenyl]sulfonyl]phenyl)acetamide
0.00003
-
 pH 7.5, 37°, free MMP-8 HPLC-FLU Homo sapiens N2-(biphenyl-4-ylsulfonyl)-N-hydroxyglycinamide
0.000034
-
 pH 7.5, 37°, free MMP-8 HPLC-FLU Homo sapiens N-hydroxy-2-(2-[[4-(4-methoxyphenoxy)phenyl]sulfonyl]phenyl)acetamide
0.000063
-
 pH 7.5, 37°, free MMP-8 HPLC-FLU Homo sapiens N2-(biphenyl-4-ylsulfonyl)-N-hydroxyglycinamide
0.000065
-
 pH 7.5, 37°, free MMP-8 FLU plates read Homo sapiens N-hydroxy-N2-[(4'-methoxybiphenyl-4-yl)sulfonyl]-N2-(propan-2-yloxy)glycinamide
0.000065
-
 pH 7.5, 37°, free MMP-8 FLU plates read Homo sapiens N-hydroxy-N2-[(4-phenoxyphenyl)sulfonyl]-N2-(propan-2-yloxy)glycinamide
0.00023
-
 pH 7.5, 37°, free MMP-8 HPLC-FLU Homo sapiens N-hydroxy-N2-[(4'-methoxybiphenyl-4-yl)sulfonyl]-N2-(propan-2-yloxy)glycinamide
0.00025
-
 pH 7.5, 37°, free MMP-8 HPLC-FLU Homo sapiens N-hydroxy-N2-[(4-phenoxyphenyl)sulfonyl]-N2-(propan-2-yloxy)glycinamide
0.00026
-
 pH 7.5, 37°, free MMP-8 FLU plates read Homo sapiens N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)glycinamide
0.00033
-
 pH 7.5, 37°, free MMP-8 HPLC-FLU Homo sapiens N-hydroxy-N2-[(4'-methoxybiphenyl-4-yl)sulfonyl]-N2-(propan-2-yloxy)glycinamide
0.000346
-
 pH 7.5, 37°, free MMP-8 HPLC-FLU Homo sapiens N-hydroxy-N2-[(4-phenoxyphenyl)sulfonyl]-N2-(propan-2-yloxy)glycinamide
0.000435
-
 pH 7.5, 37°, free MMP-8 HPLC-FLU Homo sapiens N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)glycinamide
0.000497
-
 pH 7.5, 37°, free MMP-8 HPLC-FLU Homo sapiens N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)glycinamide