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Literature summary for 3.4.24.34 extracted from
- Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase (2004), J. Immunol., 172, 7791-7803.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | resistant to inhibition by tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | binding of MMP-8 to the surface of polymorphonuclear cells promotes stability | Homo sapiens | 9986 | - |
| membrane | - |
Homo sapiens | 16020 | - |
| membrane | membrane-bound MMP-8 accounts for 92% of the matrix metalloproteinase-mediated polymorphonuclear cell surface type I collagenase activity | Mus musculus | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| polymorphonuclear cell | MMP-8 is expressed in an inducible manner in both pro- and active forms on the surface of polymorphonuclear cell | Homo sapiens | - |
| polymorphonuclear cell | TIMP(tissue inhibitor of metalloproteinase)-resistant, active MMP-8 expressed on the surface of activated polymorphonuclear cells is likely to be an important form of MMP-8, regulating the lung inflammation and collagen turnover in vivo | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha1-proteinase inhibitor + H2O | - |
Homo sapiens | ? | - |
? |  |
| Collagen + H2O | type I and type II | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| metalloproteinase-8 | - |
Mus musculus |
| metalloproteinase-8 | - |
Homo sapiens |
| MMP-8 | - |
Mus musculus |
| MMP-8 | - |
Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
t1/2 for soluble MMP-8: 7.5 h, membrane-bound MMP-8 retains more than 80% of its activity after 18 h. Binding of MMP-8 to the surface of polymorphonuclear cells promotes stability | Homo sapiens |
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