Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(E)-N-(naphthalen-1-yl)-N'-(4-oxo-2-phenylquinazolin-3(4H)-yl)acetimidamide | low inhibitory activity | Bacillus thermoproteolyticus | |
2-(4-chlorophenyl) quinazolin-4(3H)-one | low inhibitory activity | Bacillus thermoproteolyticus | |
2-(4-methylphenyl) quinazolin-4(3H)-one | low inhibitory activity | Bacillus thermoproteolyticus | |
2-(4-methylphenyl)-3-(1,3-thiazol-2-yl) quinazolin-4(3H)-one | - |
Bacillus thermoproteolyticus | |
2-(4-oxo-2-methylquinazolin-3(4H)-yl) guanidine | low inhibitory activity | Bacillus thermoproteolyticus | |
2-benzamido-N-(3-(4-oxo-2-phenylquinazolin-3(4H)-yl)propyl)benzamide | low inhibitory activity | Bacillus thermoproteolyticus | |
2-chloro-N-(2-methyl-4-oxoquinazolin-3(4H)-yl)acetamide | low inhibitory activity | Bacillus thermoproteolyticus | |
2-ethylquinazolin-4(3H)-one | - |
Bacillus thermoproteolyticus | |
2-phenyl-3-(1, 3-thiazol-2-yl) quinazolin-4(3H)-one | low inhibitory activity | Bacillus thermoproteolyticus | |
2-phenyl-3-[[(1E)-phenylmethylene] amino]-2,3-dihydroquinazolin-4(1H)-one | low inhibitory activity | Bacillus thermoproteolyticus | |
3-(2-aminoethyl)-2-(4-methylphenyl) quinazolin-4(3H)-one | low inhibitory activity | Bacillus thermoproteolyticus | |
3-(2-hydroxyethyl) quinazolin-4(3H)-one | low inhibitory activity | Bacillus thermoproteolyticus | |
3-(3-aminopropyl)-2-(4-methylphenyl) quinazolin-4(3H)-one | low inhibitory activity | Bacillus thermoproteolyticus | |
3-(4-iodophenyl)-2-phenylquinazolin-4(3H)-one | low inhibitory activity | Bacillus thermoproteolyticus | |
3-(isopropylideneamino)-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-one | potent inhibitor | Bacillus thermoproteolyticus | |
3-([(1E)-[4-(dimethylamino) phenyl]methylene]amino)-2-methylquinazolin-4(3H)-one | - |
Bacillus thermoproteolyticus | |
3-([(1E)-[4-(dimethylamino) phenyl]methylene]amino)-2-phenylquinazolin-4(3H)-one | - |
Bacillus thermoproteolyticus | |
3-amino-2-(4-chlorophenyl)quinazolin-4(3H)-one | - |
Bacillus thermoproteolyticus | |
3-amino-2-(4-nitrophenyl)quinazolin-4(3H)-one | - |
Bacillus thermoproteolyticus | |
3-amino-2-(hydrazinomethyl) quinazolin-4(3H)-one | low inhibitory activity | Bacillus thermoproteolyticus | |
3-amino-2-(trifluoromethyl) quinazolin-4(3H)-one | - |
Bacillus thermoproteolyticus | |
3-amino-2-methylquinazolin-4(3H)-one | - |
Bacillus thermoproteolyticus | |
3-phenyl-2-(trifluoromethyl) quinazolin-4(3H)-one | potent inhibitor | Bacillus thermoproteolyticus | |
3-[[(1E)-(2-hydroxynaphthalen-1-yl)methylene]amino]-2-phenylquinazolin-4(3H)-one | low inhibitory activity | Bacillus thermoproteolyticus | |
3-[[(1E)-(3-chlorophenyl)methylene]amino]-2-phenylquinazolin-4(3H)-one | - |
Bacillus thermoproteolyticus | |
3-[[(1E)-(4-fluorophenyl)methylene]amino]-2-phenylquinazolin-4(3H)-one | low inhibitory activity | Bacillus thermoproteolyticus | |
4-methyl-N-(2-methyl-4-oxoquinazolin-3(4H)-yl)benzamide | low inhibitory activity | Bacillus thermoproteolyticus | |
ethanimidic acid N-[4-oxo-2-phenyl-3(4H)-quinazolinyl]-ethyl ester | - |
Bacillus thermoproteolyticus | |
ethyl (4-oxo-3,4-dihydroquinazolin-2-yl)acetate | low inhibitory activity | Bacillus thermoproteolyticus | |
methyl 2-[(trifluoroacetyl) amino] benzoate | low inhibitory activity | Bacillus thermoproteolyticus | |
additional information | not inhibited by 2-phenyl-3-[(E)-phenyldiazenyl]-1,2,3,4-tetrahydro-10H[1,2,4]triazino[6,1b]-quinazolin-10-one, 3-mesityl-2-phenylquinazolin-4(3H)-one, 3-(2-hydroxyethyl)-2-methylquinazolin-4(3H)-one, and 3-amino-2-phenylquinazolin-4(3H)-one | Bacillus thermoproteolyticus | |
N-(2-methyl-4-oxoquinazolin-3(4H)-yl)acetamide | low inhibitory activity | Bacillus thermoproteolyticus | |
N-(2-methyl-4-oxoquinazolin-3(4H)-yl)benzamide | low inhibitory activity | Bacillus thermoproteolyticus | |
N-(2-phenyl-4-oxoquinazolin-3(4H)-yl)acetamide | low inhibitory activity | Bacillus thermoproteolyticus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | four Ca2+ ions are required for thermostability | Bacillus thermoproteolyticus | |
Zn2+ | a single catalytic Zn2+ ion is essential for hydrolytic activity | Bacillus thermoproteolyticus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus thermoproteolyticus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N'-[3-(2-furyl)acryloyl]glycyl-L-leucinamide + H2O | - |
Bacillus thermoproteolyticus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TLN | - |
Bacillus thermoproteolyticus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000115 | - |
3-phenyl-2-(trifluoromethyl) quinazolin-4(3H)-one | at pH 7.0 and 25°C | Bacillus thermoproteolyticus | |
0.000243 | - |
3-(isopropylideneamino)-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-one | at pH 7.0 and 25°C | Bacillus thermoproteolyticus | |
0.00125 | - |
2-ethylquinazolin-4(3H)-one | at pH 7.0 and 25°C | Bacillus thermoproteolyticus | |
0.0183 | - |
3-([(1E)-[4-(dimethylamino) phenyl]methylene]amino)-2-methylquinazolin-4(3H)-one | at pH 7.0 and 25°C | Bacillus thermoproteolyticus | |
0.0379 | - |
3-amino-2-(trifluoromethyl) quinazolin-4(3H)-one | at pH 7.0 and 25°C | Bacillus thermoproteolyticus | |
0.042 | - |
3-([(1E)-[4-(dimethylamino) phenyl]methylene]amino)-2-phenylquinazolin-4(3H)-one | at pH 7.0 and 25°C | Bacillus thermoproteolyticus | |
0.0549 | - |
3-amino-2-methylquinazolin-4(3H)-one | at pH 7.0 and 25°C | Bacillus thermoproteolyticus | |
0.0593 | - |
2-(4-methylphenyl)-3-(1,3-thiazol-2-yl) quinazolin-4(3H)-one | at pH 7.0 and 25°C | Bacillus thermoproteolyticus | |
3.12 | - |
3-amino-2-(4-nitrophenyl)quinazolin-4(3H)-one | at pH 7.0 and 25°C | Bacillus thermoproteolyticus | |
4 | - |
3-[[(1E)-(3-chlorophenyl)methylene]amino]-2-phenylquinazolin-4(3H)-one | at pH 7.0 and 25°C | Bacillus thermoproteolyticus | |
106 | - |
ethanimidic acid N-[4-oxo-2-phenyl-3(4H)-quinazolinyl]-ethyl ester | at pH 7.0 and 25°C | Bacillus thermoproteolyticus | |
10100 | - |
3-amino-2-(4-chlorophenyl)quinazolin-4(3H)-one | at pH 7.0 and 25°C | Bacillus thermoproteolyticus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000115 | - |
at pH 7.0 and 25°C | Bacillus thermoproteolyticus | 3-phenyl-2-(trifluoromethyl) quinazolin-4(3H)-one | |
0.0002477 | - |
at pH 7.0 and 25°C | Bacillus thermoproteolyticus | 3-(isopropylideneamino)-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-one | |
0.00125 | - |
at pH 7.0 and 25°C | Bacillus thermoproteolyticus | 2-ethylquinazolin-4(3H)-one | |
0.01832 | - |
at pH 7.0 and 25°C | Bacillus thermoproteolyticus | 3-([(1E)-[4-(dimethylamino) phenyl]methylene]amino)-2-methylquinazolin-4(3H)-one | |
0.03786 | - |
at pH 7.0 and 25°C | Bacillus thermoproteolyticus | 3-amino-2-(trifluoromethyl) quinazolin-4(3H)-one | |
0.04203 | - |
at pH 7.0 and 25°C | Bacillus thermoproteolyticus | 3-([(1E)-[4-(dimethylamino) phenyl]methylene]amino)-2-phenylquinazolin-4(3H)-one | |
0.05489 | - |
at pH 7.0 and 25°C | Bacillus thermoproteolyticus | 3-amino-2-methylquinazolin-4(3H)-one | |
0.07685 | - |
at pH 7.0 and 25°C | Bacillus thermoproteolyticus | 2-(4-methylphenyl)-3-(1,3-thiazol-2-yl) quinazolin-4(3H)-one | |
3.118 | - |
at pH 7.0 and 25°C | Bacillus thermoproteolyticus | 3-amino-2-(4-nitrophenyl)quinazolin-4(3H)-one | |
4.002 | - |
at pH 7.0 and 25°C | Bacillus thermoproteolyticus | 3-[[(1E)-(3-chlorophenyl)methylene]amino]-2-phenylquinazolin-4(3H)-one | |
12.74 | - |
at pH 7.0 and 25°C | Bacillus thermoproteolyticus | 3-amino-2-(4-chlorophenyl)quinazolin-4(3H)-one | |
122.6 | - |
at pH 7.0 and 25°C | Bacillus thermoproteolyticus | ethanimidic acid N-[4-oxo-2-phenyl-3(4H)-quinazolinyl]-ethyl ester |