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Literature summary for 3.4.24.23 extracted from

  • Grindel, B.; Martinez, J.; Pennington, C.; Muldoon, M.; Stave, J.; Chung, L.; Farach-Carson, M.
    Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior (2014), Matrix Biol., 36, 64-76.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.23

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Homo sapiens
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
perlecan + H2O Homo sapiens i.e. HSPG2, a large heparan sulfate proteoglycan, expressed in the basement membrane underlying epithelial and endothelial cells, proteolytic degradation ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09237
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Source Tissue

Source Tissue Comment Organism Textmining
prostate cancer cell line invasive prostate cancer cells, high enzyme expression level Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
perlecan + H2O i.e. HSPG2, a large heparan sulfate proteoglycan, expressed in the basement membrane underlying epithelial and endothelial cells, proteolytic degradation Homo sapiens ?
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 ?
perlecan + H2O high activity, the enzyme produces discrete perlecan fragments corresponding to an origin in immunoglobulin repeat region domain IV, the enzyme cleaves every subpart of recombinantly generated perlecan domain IV. Identification and characterization of perlecan Dm IV-3 sites of cleavage by enzyme MMP-7, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
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 Homo sapiens
MMP7
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 Homo sapiens

General Information

General Information Comment Organism
physiological function a long C-terminal portion of perlecan domain IV, DmIV-3, induces a strong clustering phenotype in the metastatic PCa cell lines, PC-3 and C4-2. MMP-7 digestion of Dm IV-3 reverses the clustering effect into one favoring cell dispersion, pro-metastasis effects of MMP-7 on prostate cancer cells Homo sapiens