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Literature summary for 3.4.24.23 extracted from

  • Almendro, V.; Ametller, E.; Garcia-Recio, S.; Collazo, O.; Casas, I.; Auge, J.M.; Maurel, J.; Gascon, P.
    The role of MMP7 and its cross-talk with the FAS/FASL system during the acquisition of chemoresistance to oxaliplatin (2009), PLoS ONE, 4, e4728.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell wild-type HCT-116 and oxaliplatin-resistant RHCT-116 p53 positive- and p53 negative cell lines Homo sapiens
-
HT-29 cell wild-type HT-29 and oxaliplatin-resistant RHT-29 cell lines Homo sapiens
-
additional information MMP7 basal expression is higher in the oxaliplatin-resistant compared to the parental cell lines Homo sapiens
-

Synonyms

Synonyms Comment Organism
MMP7
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens MMP7 is upregulated by oxaliplatin in colon cancer cell lines. FasL expression is also upregulated by oxaliplatin treatment but decreased in the plasma membrane of resistant cells up

General Information

General Information Comment Organism
physiological function MMP7 is a metalloproteinase with prometastatic function related to early tumor development, metastatic potential, and clinical outcome in cancer. MMP7 is related to the acquisition of oxaliplatin-resistance in cancer cell lines and its inhibition restores drug sensitivity by increasing Fas receptor Homo sapiens