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Literature summary for 3.4.24.23 extracted from

  • Wilson, C.L.; Schmidt, A.P.; Pirilae, E.; Valore, E.V.; Ferri, N.; Sorsa, T.; Ganz, T.; Parks, W.C.
    Differential processing of alpha- and beta-defensin precursors by matrix metalloproteinase-7 (MMP-7) (2009), J. Biol. Chem., 284, 8301-8311.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information a form of MMP-7 containing an Glu to Gln mutation in the catalytic domain is catalytically inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-alpha-defensin + H2O Homo sapiens
-
alpha-defensin + alpha-defensin propeptide
-
?
pro-beta-defensin + H2O Homo sapiens
-
beta-defensin + beta-defensin propeptide
-
?
pro-HNP-1 + H2O Homo sapiens i.e. pro-human neutrophil peptide-1, in a cell-based assay system HNP-1 + HNP-1 propeptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-alpha-defensin + H2O
-
Homo sapiens alpha-defensin + alpha-defensin propeptide
-
?
pro-beta-defensin + H2O
-
Homo sapiens beta-defensin + beta-defensin propeptide
-
?
pro-HNP-1 + H2O i.e. pro-human neutrophil peptide-1, in a cell-based assay system Homo sapiens HNP-1 + HNP-1 propeptide
-
?
pro-HNP-1 + H2O i.e. pro-human neutrophil peptide-1 Homo sapiens HNP-1 + HNP-1 propeptide
-
?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
-
Homo sapiens
MMP-7
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens