Cloned (Comment) | Organism |
---|---|
MMP-7 genotyping in healthy persons and liver cirrhosis patients, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A15T | a naturally occuring polymorphism, not involved in liver cirrhosis | Homo sapiens |
G137D | a naturally occuring polymorphism, the Asp137 genetic variant of MMP-7 is susceptible to liver cirrhosis, MMP-7 D137 shows an increased level in its distribution to the plasma membrane of HSCs and an enhanced ability on cell migration, overview. It converts to its active form in specific microdomains | Homo sapiens |
R77H | a naturally occuring polymorphism, not involved in liver cirrhosis | Homo sapiens |
V470M | a naturally occuring polymorphism, not involved in liver cirrhosis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | - |
Homo sapiens | |
o-phenanthroline | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | the MMP-7 Asp137 genetic variant is preferentially localized to the cell surface plasma membrane | Homo sapiens | 9986 | - |
cytosol | wild-type MMP-7 Gly137 is distributed both in the membrane and cytosol fractions | Homo sapiens | 5829 | - |
extracellular | secretory MMP-7 has to be recruited onto the cell surface to hydrolyze biologically relevant molecules | Homo sapiens | - |
- |
plasma membrane | the MMP-7 Asp137 genetic variant is preferentially localized to the cell surface plasma membrane | Homo sapiens | 5886 | - |
plasma membrane | wild-type MMP-7 Gly137 is distributed both in the membrane and cytosol fractions | Homo sapiens | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
Taiwanese population | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
additional information | MMP-7 expression analysis in healthy persons and liver cirrhosis patients, overview | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase-7 | - |
Homo sapiens |
MMP-7 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | a nonsynonymous genetic variant D137 of matrix metalloproteinase-7 confers risk of liver cirrhosis, overview | Homo sapiens |
additional information | secretory MMP-7 has to be recruited onto the cell surface to hydrolyze biologically relevant molecules, MMP-7 docks to the cell surface membrane via CD44 heparan sulfate proteoglycan, cholesterol sulfate, and CD151 binding | Homo sapiens |