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Literature summary for 3.4.24.23 extracted from

  • Hung, T.M.; Chang, S.C.; Yu, W.H.; Wang, Y.W.; Huang, C.; Lu, S.C.; Lee, P.H.; Chang, M.F.
    A novel nonsynonymous variant of matrix metalloproteinase-7 confers risk of liver cirrhosis (2009), Hepatology, 50, 1184-1193.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
MMP-7 genotyping in healthy persons and liver cirrhosis patients, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
A15T a naturally occuring polymorphism, not involved in liver cirrhosis Homo sapiens
G137D a naturally occuring polymorphism, the Asp137 genetic variant of MMP-7 is susceptible to liver cirrhosis, MMP-7 D137 shows an increased level in its distribution to the plasma membrane of HSCs and an enhanced ability on cell migration, overview. It converts to its active form in specific microdomains Homo sapiens
R77H a naturally occuring polymorphism, not involved in liver cirrhosis Homo sapiens
V470M a naturally occuring polymorphism, not involved in liver cirrhosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
Homo sapiens
o-phenanthroline
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface the MMP-7 Asp137 genetic variant is preferentially localized to the cell surface plasma membrane Homo sapiens 9986
-
cytosol wild-type MMP-7 Gly137 is distributed both in the membrane and cytosol fractions Homo sapiens 5829
-
extracellular secretory MMP-7 has to be recruited onto the cell surface to hydrolyze biologically relevant molecules Homo sapiens
-
-
plasma membrane the MMP-7 Asp137 genetic variant is preferentially localized to the cell surface plasma membrane Homo sapiens 5886
-
plasma membrane wild-type MMP-7 Gly137 is distributed both in the membrane and cytosol fractions Homo sapiens 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
Taiwanese population
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Homo sapiens
-
liver
-
Homo sapiens
-
additional information MMP-7 expression analysis in healthy persons and liver cirrhosis patients, overview Homo sapiens
-

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
-
Homo sapiens
MMP-7
-
Homo sapiens

General Information

General Information Comment Organism
malfunction a nonsynonymous genetic variant D137 of matrix metalloproteinase-7 confers risk of liver cirrhosis, overview Homo sapiens
additional information secretory MMP-7 has to be recruited onto the cell surface to hydrolyze biologically relevant molecules, MMP-7 docks to the cell surface membrane via CD44 heparan sulfate proteoglycan, cholesterol sulfate, and CD151 binding Homo sapiens