Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Fas ligand | treatment with Fas ligand, Fas-L, increases levels of active MMP-7 by 80% | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview | Mus musculus |
additional information | MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
batimastat | i.e. BB-94, BB-94 significantly reduces the amount of N-cadherin fragment produced in response to Fas-L | Homo sapiens | |
batimastat | - |
Mus musculus | |
additional information | MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview | Homo sapiens | |
additional information | MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-cadherin + H2O | Mus musculus | recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% | ? | - |
? | |
N-cadherin + H2O | Homo sapiens | recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% | ? | - |
? | |
N-cadherin + H2O | Mus musculus C57/BL6J | recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
C57BL/6J mice | - |
Mus musculus C57/BL6J | - |
C57BL/6J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | MMP-7 activity is significantly higher in atherosclerotic plaques than internal mammary arteries | Homo sapiens | - |
vascular smooth muscle cell | - |
Mus musculus | - |
vascular smooth muscle cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | MMP-7 assay using DQ-gelatin fluorescent substrate | Mus musculus | ? | - |
? | |
additional information | MMP-7 assay using DQ-gelatin fluorescent substrate | Homo sapiens | ? | - |
? | |
additional information | MMP-7 assay using DQ-gelatin fluorescent substrate | Mus musculus C57/BL6J | ? | - |
? | |
N-cadherin + H2O | - |
Mus musculus | ? | - |
? | |
N-cadherin + H2O | - |
Homo sapiens | ? | - |
? | |
N-cadherin + H2O | recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% | Mus musculus | ? | - |
? | |
N-cadherin + H2O | recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% | Homo sapiens | ? | - |
? | |
N-cadherin + H2O | - |
Mus musculus C57/BL6J | ? | - |
? | |
N-cadherin + H2O | recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% | Mus musculus C57/BL6J | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloprotease-7 | - |
Mus musculus |
matrix metalloprotease-7 | - |
Homo sapiens |
MMP-7 | - |
Mus musculus |
MMP-7 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00001 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | batimastat |
General Information | Comment | Organism |
---|---|---|
physiological function | MMP-7 mediates cleavage of N-cadherin and promotes vascular smooth muscle cell apoptosis, that can lead to thinning of the fibrous cap and atherosclerotic plaque instability | Homo sapiens |
physiological function | MMP-7 mediates cleavage of N-cadherin and promotes vascular smooth muscle cell apoptosis, that can lead to thinning of the fibrous cap and plaque instability | Mus musculus |