Literature summary for 3.4.24.23 extracted from

Adachi, Y.; Li, R.; Yamamoto, H.; Min, Y.; Piao, W.; Wang, Y.; Imsumran, A.; Li, H.; Arimura, Y.; Lee, C.T.; Imai, K.; Carbone, D.P.; Shinomura, Y.
Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin (2009), Carcinogenesis, 30, 1305-1313.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BxPC-3 cell	-	Homo sapiens	-
colorectal adenocarcinoma cell	-	Homo sapiens	-
gastric adenocarcinoma cell	-	Homo sapiens	-
gastrointestinal cancer cell	-	Homo sapiens	-
HT-29 cell	-	Homo sapiens	-
MKN-45 cell	-	Homo sapiens	-
pancreatic adenocarcinoma cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MMP-7	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	dominant negative insulin-like growth factor-I receptor, i.e. IGF-IR/dn, suppresses MMP-7 expression in invasive subcutaneous tumors. IGF-stimulated secretion of matrilysin and IGF-IR/dn blocks IGF-mediated matrilysin induction in three gastrointestinal cancers, overview	down
Homo sapiens	IGF stimulates matrilysin expression in gastrointestinal cancer cell lines	up

General Information

General Information	Comment	Organism
malfunction	MMP-7 is involved in gastrointestinal cancer cell invasiveness	Homo sapiens

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Release 2023.1 (January 2023)