Protein Variants | Comment | Organism |
---|---|---|
additional information | host MMP-7 contributes to mammary tumor growth in the bone microenvironment after injection of human tumor cells into tibias of mice | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone cancer cell | the matrix metalloproteinases MMP-2, MMP-3, MMP-7, MMP-9, and MMP-13 are highly expressed in the tumor-bone microenvironment, and, of these, MMP-7 and MMP-9 are found to be localized to bone-resorbing osteoclasts in human breast-to-bone metastases | Homo sapiens | - |
osteoclast | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase-7 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | osteoclast-derived MMP-7 significantly contributes to tumor growth and tumor-induced osteolysis, overview. Solubilization of RANKL by MMP-7 is a potential mechanism through which MMP-7 mediates mammary tumor-induced osteolysis, mechanism, overview. MMP-7 is capable of processing a number of nonmatrix molecules to soluble active forms that have profound effects on cell-cell communication, such as RANKL, a crucial mediator of osteoclast precursor recruitment and maturation | Homo sapiens |