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Literature summary for 3.4.24.23 extracted from

  • Yue, W.; Sun, Q.; Landreneau, R.; Wu, C.; Siegfried, J.M.; Yu, J.; Zhang, L.
    Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression (2009), Cancer Res., 69, 6339-6346.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.23

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular MMP-7 is secreted Homo sapiens
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-

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung cancer cell expression levels of fibulin-5 and MMP-7 are inversely correlated in lung tumors Homo sapiens
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NCI-H1299 cell
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 Homo sapiens
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NCI-H460 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
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 Homo sapiens
MMP-7
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens fibulin-5 downregulates MMP-7, suppression of fibulin-5, as well as deletion of its RGD motif, induces MMP-7 expression in lung. Suppression of MMP-7 expression by fibulin-5 is mediated by an integrin-binding RGD motif via the extracellular signal-regulated kinase pathway down

General Information

General Information Comment Organism
malfunction epigenetic silencing or knockdown of fibulin-5, a vascular ligand for integrin receptors and a suppressor of lung cancer invasion and metastasis, promotes lung cancer invasion and metastasis by activating MMP-7 expression through the ERK pathway, injection of fibulin-5-deficient and unmodified H-460 cells into nude mice, overview Homo sapiens