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Literature summary for 3.4.24.23 extracted from

  • Berton, A.; Selvais, C.; Lemoine, P.; Henriet, P.; Courtoy, P.J.; Marbaix, E.; Emonard, H.
    Binding of matrilysin-1 to human epithelial cells promotes its activity (2007), Cell. Mol. Life Sci., 64, 610-620.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information binding of matrilysin-1 to epithelial cells via cholesterol sulfate, protamine or heparin promotes its activity and renders the enzyme resistant to TIMP-2, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
MMPI-II a small synthetic inhibitor of 514 Da Homo sapiens
TIMP-2
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
intracellular pro-MMP-7 is diffusely distributed in epithelial cells of the endometrium, while the mature enzyme is located at the plasma membrane Homo sapiens 5622
-
plasma membrane pro-MMP-7 is diffusely distributed in epithelial cells of the endometrium, while the mature enzyme is located at the plasma membrane Homo sapiens 5886
-
soluble pro-MMP-7 is diffusely distributed in epithelial cells of the endometrium, while the mature enzyme is located at the plasma membrane Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ MMP-7 is a zinc-dependent endoproteinase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens matrilysin-1 modulates crucial biological events by processing many epithelial cell surface-associated effectors, MMP-7 binds to epithelial and Ishikawa cells via cholesterol sulfate, protamine, or heparin, cell binding mechanism, MMP-7 can directly interact with the cells, without proMMP-7 having to bind first to the cell surface for local activation, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09237
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endometrium
-
Homo sapiens
-
epithelial cell pro-MMP-7 is diffusely distributed in epithelial cells of the endometrium, while the mature enzyme is located at the plasma membrane Homo sapiens
-
Ishikawa cell endometrial carcinoma-derived cell line Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
quantitative determination of binding sites for MMP-7 on epithelial cells and Ishikawa cells, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O fluorescence-labeled substrate Homo sapiens ?
-
?
additional information matrilysin-1 modulates crucial biological events by processing many epithelial cell surface-associated effectors, MMP-7 binds to epithelial and Ishikawa cells via cholesterol sulfate, protamine, or heparin, cell binding mechanism, MMP-7 can directly interact with the cells, without proMMP-7 having to bind first to the cell surface for local activation, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
matrilysin-1
-
Homo sapiens
Matrix metalloproteinase-7
-
Homo sapiens
MMP-7
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000009
-
TIMP-2 pH 7.4, 37°C, soluble enzyme Homo sapiens
0.000027
-
MMPI-II pH 7.4, 37°C, soluble enzyme Homo sapiens
0.000053
-
MMPI-II pH 7.4, 37°C, membrane-bound enzyme Homo sapiens
0.000064
-
TIMP-2 pH 7.4, 37°C, membrane-bound enzyme Homo sapiens