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Literature summary for 3.4.24.23 extracted from
- States of tryptophyl residues and stability of recombinant human matrix metalloproteinase 7 (matrilysin) as examined by fluorescence (2000), J. Biochem., 128, 363-369.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | matrilysin is overexpressed in cancer cells of variuos organs including prostate, colorectum, brain, and stomach, important role in tumor invasion and metastasis | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| prepromatrliysin cDNA expressed in Escherichia coli | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | contains a zinc ion essential for enzyme activity as well as a second zinc ion necessary for enzyme stability | Homo sapiens |  |
| Na+ | activity is increased by adding NaCl, doubled with 3 M | Homo sapiens | |
| Zn2+ | contains 2 calcium ions essential for enzyme stability | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 19000 | - |
mature form | Homo sapiens |
| 28000 | - |
proform | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | enzyme is believed to take part in processes involving physiological and pathological degradations, such as development, differentiation, tissue morphogenesis, wound healing, ovulation, rheumatoid arthritis, and tumor invasion | ? | - |
? | |
Organic Solvent Stability
| Organic Solvent | Comment | Organism |
|---|---|---|
| guanidine-HCl | half of inactivation induced at 0.8 M | Homo sapiens |
| urea | half of inactivation induced at 2 M urea | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7-methoxycoumarin-4acetylPLGL(L-2,3-diaminopropionyl)AR + H2O | - |
Homo sapiens | 7-methoxycoumarin-4acetyl-PLG + ? | - |
? | |
| Azocoll + H2O | - |
Homo sapiens | ? | - |
? | |
| Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| Gelatin + H2O | type I, II, IV and V | Homo sapiens | ? | - |
? | |
| Laminin + H2O | - |
Homo sapiens | ? | - |
? | |
| additional information | enzyme is believed to take part in processes involving physiological and pathological degradations, such as development, differentiation, tissue morphogenesis, wound healing, ovulation, rheumatoid arthritis, and tumor invasion | Homo sapiens | ? | - |
? | |
| Proteoglycan + H2O | - |
Homo sapiens | ? | - |
? | |
| type IV basement membrane collagen + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Matrix metalloproteinase 7 | - |
Homo sapiens |
| MMP-7 | - |
Homo sapiens |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | 55 | - |
Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 69 | 76 | 50% of the activity is lost upon incubation at 69°C for 10 min, activity decreases to zero as temperature is raised to 76°C | Homo sapiens |
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Release 2023.1 (January 2023)
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