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Literature summary for 3.4.24.21 extracted from
- Collagen processing and cuticle formation is catalysed by the astacin metalloprotease DPY-31 in free-living and parasitic nematodes (2010), Int. J. Parasitol., 40, 533-542.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinantly expressed as a His-tagged fusion in Escherichia coli | Brugia malayi |
| recombinantly expressed as a His-tagged fusion in Escherichia coli | Haemonchus contortus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Brugia malayi |  |
| 1,10-phenanthroline | - |
Haemonchus contortus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
recombinant His-tagged protein | Brugia malayi |
| 50000 | - |
recombinant His-tagged protein | Haemonchus contortus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Brugia malayi | - |
- |
- |
| Caenorhabditis elegans | - |
- |
- |
| Haemonchus contortus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | putative | Brugia malayi |
| glycoprotein | putative | Haemonchus contortus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| using Ni-NTA chromatography | Brugia malayi |
| using Ni-NTA chromatography | Haemonchus contortus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gut | - |
Caenorhabditis elegans | - |
| secretory cell | - |
Caenorhabditis elegans | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| SQT-3 + H2O | - |
Brugia malayi | ? | - |
? | |
| SQT-3 + H2O | - |
Haemonchus contortus | ? | - |
? | |
| Suc-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Brugia malayi | Suc-Ala-Ala-Ala + 4-nitroaniline | - |
? | |
| Suc-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Caenorhabditis elegans | Suc-Ala-Ala-Ala + 4-nitroaniline | - |
? | |
| Suc-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Haemonchus contortus | Suc-Ala-Ala-Ala + 4-nitroaniline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DPY-31 | - |
Brugia malayi |
| DPY-31 | - |
Caenorhabditis elegans |
| DPY-31 | - |
Haemonchus contortus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Brugia malayi |
| 25 | - |
assay at | Caenorhabditis elegans |
| 25 | - |
assay at | Haemonchus contortus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Brugia malayi |
| 8 | - |
assay at | Caenorhabditis elegans |
| 8 | - |
assay at | Haemonchus contortus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | heterologous expression of the Haemonchus contortus dpy-31 orthologue in a Caenorhabditis elegans dpy-31 mutant results in the full rescue of the mutant body form | Caenorhabditis elegans |
| malfunction | heterologous expression of the Haemonchus contortus dpy-31 orthologue in a Caenorhabditis elegans dpy-31 mutant results in the full rescue of the mutant body form | Haemonchus contortus |
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