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Literature summary for 3.4.24.21 extracted from

  • Gomis-Ruth, F.X.; Grams, F.; Yiallouros, I.; Nar, H.; Kusthardt, U.; Zwilling, R.; Bode, W.; Stöcker, W.
    Crystal structures, spectroscopic features, and catalytic properties of cobalt(II), copper(II), nickel(II), and mercury(II) derivatives of the zinc endopeptidase astacin. A correlation of structure and proteolytic activity (1994), J. Biol. Chem., 269, 17111-17117.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
Astacus astacus Astacus astacus
X-ray crystallography of Cu(II)-astacin, Co(II)-astacin and Ni(II)-astacin Astacus astacus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Astacus astacus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ activation of apoenzyme, can replace Zn2+ as catalytic ion yielding 140% of the activity of the zinc-containing enzyme, pentavalent metal coordination Astacus astacus
Cu2+ activation of apoenzyme, can replace Zn2+ as catalytic ion yielding 37% of the activity of the zinc-containing enzyme, pentavalent metal coordination Astacus astacus
additional information no apoenzyme activation by Ni2+ or Hg2+ with their octahedral and tetrahedral coordination Astacus astacus
Zn2+ requirement Astacus astacus
Zn2+ zinc metalloenzyme Astacus astacus
Zn2+ zinc-binding consensus sequence Astacus astacus
Zn2+ pentavalent metal coordination Astacus astacus

Organism

Organism UniProt Comment Textmining
Astacus astacus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
digestive juice
-
 Astacus astacus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Succinyl-Ala-Ala-Ala 4-nitroanilide + H2O
-
 Astacus astacus Succinyl-Ala-Ala-Ala + p-nitroaniline
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Astacus astacus