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Literature summary for 3.4.24.15 extracted from

  • Dalio, F.M.; Visniauskas, B.; Bicocchi, E.S.; Perry, J.C.; Freua, R.; Gesteira, T.F.; Nader, H.B.; Machado, M.F.; Tufik, S.; Ferro, E.S.; Andersen, M.L.; Toledo, C.A.; Chagas, J.R.; Oliveira, V.
    Acute cocaine treatment increases thimet oligopeptidase in the striatum of rat brain (2012), Biochem. Biophys. Res. Commun., 419, 724-727.
    View publication on PubMed
Search for more literature for 3.4.24.15

Activating Compound

Activating Compound Comment Organism Structure
cocaine cocaine treatment causes an increase in the ventral striatum in enzyme specific activity and enzyme relative mRNA amount determined by real time RT-PCR Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis by quantitative real-time PCR Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-Aib-Tyr-4-aminobenzoate specific TOP enzyme inhibitor JA-2 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-neoendorphin + H2O Rattus norvegicus
-
 ?
-
 ?
alpha-neoendorphin + H2O Rattus norvegicus Wistar
-
 ?
-
 ?
beta-neoendorphin + H2O Rattus norvegicus
-
 ?
-
 ?
beta-neoendorphin + H2O Rattus norvegicus Wistar
-
 ?
-
 ?
dynorphin 1-8 + H2O Rattus norvegicus
-
 ?
-
 ?
dynorphin 1-8 + H2O Rattus norvegicus Wistar
-
 ?
-
 ?
gondotropin-releasing hormone + H2O Rattus norvegicus
-
 ?
-
 ?
gondotropin-releasing hormone + H2O Rattus norvegicus Wistar
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P24155
-
-
Rattus norvegicus Wistar P24155
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain ventral striatum, hippocampus, and frontal cortex Rattus norvegicus
-
neuroendocrine cell
-
 Rattus norvegicus
-
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-acetyl)-Pro-Leu-Gly-Pro-dLys-(2,4-dinitrophenyl) + H2O a fluorescent-quenched substrate Rattus norvegicus ?
-
 ?
(7-methoxycoumarin-4-acetyl)-Pro-Leu-Gly-Pro-dLys-(2,4-dinitrophenyl) + H2O a fluorescent-quenched substrate Rattus norvegicus Wistar ?
-
 ?
alpha-neoendorphin + H2O
-
 Rattus norvegicus ?
-
 ?
alpha-neoendorphin + H2O
-
 Rattus norvegicus Wistar ?
-
 ?
beta-neoendorphin + H2O
-
 Rattus norvegicus ?
-
 ?
beta-neoendorphin + H2O
-
 Rattus norvegicus Wistar ?
-
 ?
dynorphin 1-8 + H2O
-
 Rattus norvegicus ?
-
 ?
dynorphin 1-8 + H2O
-
 Rattus norvegicus Wistar ?
-
 ?
gondotropin-releasing hormone + H2O
-
 Rattus norvegicus ?
-
 ?
gondotropin-releasing hormone + H2O
-
 Rattus norvegicus Wistar ?
-
 ?

Synonyms

Synonyms Comment Organism
TOP
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus cocaine treatment causes an increase in the ventral striatum in enzyme specific activity and enzyme relative mRNA amount determined by real time RT-PCR up

General Information

General Information Comment Organism
metabolism enzyme activity changes in the brain might play important role in the balance of neuropeptide level correlated with cocaine effects Rattus norvegicus
physiological function the enzyme is implicated in the processing of opioid peptides, including, beta-neoendorphin, alpha-neoendorphin, dynorphin 1-8 and nociceptin/orphanin, modifications on TOP activity can potentially result in alterations in the metabolism of these neuropeptides and in vivo could be related to cocaine addiction Rattus norvegicus