Protein Variants | Comment | Organism |
---|---|---|
E502A | complete loss of enzymatic activity | Rattus norvegicus |
H473A | complete loss of enzymatic activity | Rattus norvegicus |
H474A | complete loss of enzymatic activity | Rattus norvegicus |
H477A | complete loss of enzymatic activity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
angiotensin I | inhibits hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) | Rattus norvegicus | |
angiotensin II | inhibits hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) | Rattus norvegicus | |
bradykinin | inhibits hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) | Rattus norvegicus | |
dynorphin A1-13 | inhibits hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) | Rattus norvegicus | |
LVVYPWTQRY | inhibits hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) | Rattus norvegicus | |
PVNFKFLSH | inhibits hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) | Rattus norvegicus | |
VVYPWTQRY | inhibits hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
testis | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-methoxycoumatin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) + H2O | - |
Rattus norvegicus | ? | - |
? | |
angiotensin I + H2O | 33.5% of the activity with bradykinin | Rattus norvegicus | ? | - |
? | |
angiotensin II + H2O | 7% of the activity with bradykinin | Rattus norvegicus | ? | - |
? | |
bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
LVVYPWTQRY + H2O | 0.72% of the activity with bradykinin, cleavage sites: LVVYP-/-W-/-T-/-Q-/-RY | Rattus norvegicus | ? | - |
? | |
PVNFKFLSH + H2O | 140% of the activity with bradykinin, cleavage sites: PVNF-/-K-/-F-/-LSH | Rattus norvegicus | ? | - |
? | |
VVYPWTQRY + H2O | 10.6% of the activity with bradykinin, cleavage sites: VVYPW-/-T-/-Q-/-RY | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
endopeptidase 24.15 | - |
Rattus norvegicus |
EP24.15 | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00004 | - |
dynorphin A1-13 | inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) | Rattus norvegicus | |
0.00256 | - |
LVVYPWTQRY | inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) | Rattus norvegicus | |
0.00429 | - |
angiotensin I | inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) | Rattus norvegicus | |
0.00536 | - |
bradykinin | inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) | Rattus norvegicus | |
0.00812 | - |
angiotensin II | inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) | Rattus norvegicus | |
0.01002 | - |
VVYPWTQRY | inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) | Rattus norvegicus | |
0.02776 | - |
PVNFKFLSH | inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) | Rattus norvegicus |