Literature summary for 3.4.23.46 extracted from

Mirsafian, H.; Mat Ripen, A.; Merican, A.F.; Bin Mohamad, S.
Amino acid sequence and structural comparison of BACE1 and BACE2 using evolutionary trace method (2014), ScientificWorldJournal, 2014, 482463.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
evolutionary trace analysis identifies group-specific residues in the ligand binding sites of BACE1, and BACE2, EC 3.4.23.45.The residues are Pro70, Ile110, Ile126, andAsn233 of BACE1 substituting Lys86, Leu126, Leu142, and Leu246 of BACE2, respectively.These group-specific residues would be the reason for cleavage site selectivity in BACE1 and BACE2 biological function	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P56817	-	-

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Release 2023.1 (January 2023)